Mucuna prurriens as natural medication

Mucuna prurriens as natural medication with significant less side effects than L-dopa in Parkinson


Robet Gorter, MD, PhD.


Februry 1st, 2021

Mucuna pruriens is a tropical legume native to Africa and tropical Asia and widely naturalized and cultivated.[2] Its English common names include monkey tamarind, velvet bean, Bengal velvet bean, Florida velvet bean, Mauritius velvet bean, Yokohama velvet bean, cowage, cowitch, lacuna bean, and Lyon bean.[2] The plant is notorious for the extreme itchiness it produces on contact,[3] particularly with the young foliage and the seed pods. It has agricultural and horticultural value and is used in herbalism.

mucuna puruies

Mucuna pruriens


Mucuna pruriens in Parkinson’s disease: a double blind clinical and pharmacological study

R Katzenschlager, A Evans, A Manson… – Journal of Neurology …, 2004 –

Background: The seed powder of the leguminous plant, Mucuna pruriens has long been
used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have
assessed the clinical effects and levodopa (l-dopa) pharmacokinetics following two different …

Cited by 332 Related articles All 21 versions


Neuroprotective effects of the antiparkinson drug Mucuna pruriens

BV Manyam, M Dhanasekaran… – … : An International Journal …, 2004 – Wiley Online Library

Mucuna pruriens possesses significantly higher antiparkinson activity compared with
levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson’s disease.
The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon …

Cited by 207 Related articles All 7 versions


A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias

CA Lieu, AR Kunselman, BV Manyam… – Parkinsonism & related …, 2010 – Elsevier

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced
dyskinesias (DID) in majority of patients with Parkinson’s disease (PD). Mucuna pruriens, a
legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian …

Cited by 87 Related articles All 13 versions

[CITATION] Treatment of Parkinson’s disease with the cowhage plant-Mucuna pruriens Bak.

AB Vaidya, TG Rajagopalan, NA Mankodi… – Neurology …, 1978 –

Europe PMC is an archive of life sciences journal literature.

Cited by 100 Related articles All 3 versions

Effect of antiparkinson drug HP‐200 (Mucuna pruriens) on the central monoaminergic neurotransmitters

BV Manyam, M Dhanasekaran… – … : An International Journal …, 2004 – Wiley Online Library

HP-200, which contains Mucuna pruriens endocarp, has been shown to be effective in the
treatment of Parkinson’s disease. Mucuna pruriens endocarp has also been shown to be
more effective compared to synthetic levodopa in an animal model of Parkinson’s disease …

Cited by 85 Related articles All 6 versions

Paralysis agitans and levodopa in “Ayurveda”: ancient Indian medical treatise

BV Manyam – Movement disorders: official journal of the …, 1990 – Wiley Online Library

Abstract Neurologic diseases (Vata rogas, Sanskrit) and the pharmacologic treatment of
them were described in the ancient Indian medical system—Ayurveda. This article explores
paralysis agitans, which was described under the name Kampavata. Mucuna pruriens …

Cited by 178 Related articles All 7 versions


Association of L-DOPA with recovery following Ayurveda medication in Parkinson’s disease

N Nagashayana, P Sankarankutty… – Journal of the …, 2000 – Elsevier

Ayurveda, the Indian system of traditional medicine, uses a concoction of several spices,
herbs and minerals for the treatment of diseases. In a clinical prospective study we have
evaluated the efficacy of Ayurveda treatment (a concoction in cow’s milk of powdered …

Cited by 198 Related articles All 12 versions


Method for preparing Mucuna pruriens seed extract

R Van Der Giessen, CW Olanow, A Lees… – US Patent …, 2008 – Google Patents

The present invention provides pharmaceutical compositions comprising Mucuna pruriens
seeds or one or more Mucuna pruriens seed components, Substances, fractions or mixtures
or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna …

Cited by 9 Related articles All 4 versions


Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson’s disease

S Kasture, S Pontis, A Pinna, N Schintu, L Spina… – Neurotoxicity …, 2009 – Springer

Mucuna pruriens (MP) has long been used in Indian traditional medicine as support in the
treatment of Parkinson’s disease. However, no systematic preclinical studies that aimed at
evaluating the efficacy of this substance are available to date. This study undertook an …

Cited by 86 Related articles All 12 versions

Alkaloidal constituents of Mucuna pruriens seeds

L Misra, H Wagner – Phytochemistry, 2004 – Elsevier

The seeds of Mucuna pruriens (L.) DC. after chemical analysis afforded four tetrahydroisoquinoline
alkaloids which have been isolated for the first time from M. pruriens. Out of them, two are new
whose structures have been elucidated by spectroscopic methods … Four tetrahydroisoquinoline …

Cited by 93 Related articles All 8 versions


mucuna beans

Mucuna pruriens beans from which medications are being made


  • The Plant List: A Working List of All Plant Species”. Retrieved 8 March 2015.
  • “Mucuna pruriens”. Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 8 March 2015.
  • Andersen HH, Elberling J, Arendt-Nielsen L (September 2015). “Human surrogate models of histaminergic and non-histaminergic itch” (PDF). Acta Dermato-Venereologica. 95 (7): 771–7. doi:10.2340/00015555-2146. PMID 26015312.

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