Cannabinoids (CBD) and Mistletoe can do both
by
Prof. Dr. Robert Gorter, MD, PhD. et al.
Robert Gorter, MD, PhD, is emeritus professor of the University of California San Francisco Medical School (UCSF)
Dr. Robert Gorter: “This new approach paves the way toward preventing or treating diseases of aging. There are also highly debilitating genetic diseases like DMD (Duchene Muscle Dystrophy) associated with telomere shortening that could benefit from such a potential treatment. CBD and Mistletoe are two excellent biologic, non-toxic components that exhibit this property: improving DNA repair and restoring telomeres in aging cells and protective properties to maintain healthy DNA through DNA repair up to 50%.”
Scientists at Stanford University and at UCSF say they have found a way to increase the length of telomeres (the caps that protect chromosomes in our cells from deterioration) that have been linked to disease and aging when they shorten.
Every time a cell divides, the telomeres (red) get a little shorter. They act as a built-in clock with a suicide switch. When they reach a critically shortened length, they tell the cell to stop dividing and the cell dies. This is the process of aging and eventually death
Lengthening those telomeres could lead to treatments for a number of age-related or genetic conditions, researchers at Stanford University and UCSF say.
Telomeres protect chromosomes structures on the ends of DNA strands that hold all our genetic information, from becoming damaged during the process of cell division.
However, with each successive cell division the telomeres become shortened until they reach a point where they can no longer protect chromosomes from deteriorating.
This complicates cell studies in laboratories searching for treatments for aging-related diseases difficult, as researchers can only monitor a few cell divisions before the subject cells die.
The Stanford and UCSF researchers, in an effort to increase the length of telomeres, used a modified form of RNA containing the code sequence for the active component of telomerase.
Known as TERT, the component is an enzyme created by stem cells that maintains the health of telomeres as they are passed to the next generation.
Just three applications of the modified RNA in human cells over several days increased the telomere length by up to 10%, the researchers report in the FASEB Journal.
“Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life,” says Helen Blau, a professor of immunology and microbiology. “This greatly increases the number of cells available for studies such as drug testing or disease modeling.”
This suggests that a treatment using methods like these could be brief and infrequent and still be effective. There are a number of possibilities for such treatments.
Dr. Robert Gorter: “This new approach paves the way toward preventing or treating diseases of aging and here are also highly debilitating genetic diseases associated with telomere shortening that could benefit from such a potential treatment. CBD and Mistletoe Lectines are two excellent biologic non-toxic components that exhibit these properties: improving tremendously DNA repair, especially in cancer patients and after chemotherapy and radiation, and restoring telomeres in aging individuals and preventing loss of telomeres with up to 30%-50%.”
https://www.ncbi.nlm.nih.gov/pubmed/10741725
https://www.theguardian.com/…/telomere-effect-elizabeth-blackburn-nobel- prize-medicine-chromosomes
https://www.sciencedirect.com/science/article/pii/S209050681400027X#!